盐酸哌甲酯控释片治疗注意缺陷多动障碍疗效分析

Therapeutic effect of methylphenidate hydrochloride controlled-release tablets on the attention deficit hyperactivity disorder

目的：观察长效制剂盐酸哌甲酯缓释片（专注达）单药治疗儿童不同类型注意缺陷多动障碍（ADHD）的疗效及不良反应。方法：单药使用专注达治疗临床诊断为ADHD者50例（注意缺陷为主型9例、多动-冲动为主型11例、混合型30例），治疗前后进行自身对照开放性研究。平均治疗4～8周，记录ADHD临床症状变化及不良反应。同时对其中12例进行2年的跟踪随访。结果：本组50例中显效占26．0％，有效占50．0％，无效占24．0％。注意缺陷型、多动-冲动型、混合型者显效依次为22．22％、27．27％、26．66％，有效依次为44．44％、54．54％、50．0％，总有效率达76％。结论：专注达单药治疗儿童不同类型ADHD疗效肯定，安全性好，不良反应随治疗时间的延长可以逐渐减轻或消失，未发现血压升高。

Objective： To investigate the therapeutic and adverse reaction of methylphenidate hydrochloride controlled-release tablets on the attention deficit hyperactivity disorder（ADHD）. Methods ：50 children with ADHD were treated with methylphenidate hydrochloride controlled-release tablets for 4- 8 weeks. The changes of clinical manifestation and adverse reaction were recorded. Results： The clinical of manifestation was disappeared in 26% patients ,50% patients removed half of the manifestations, and 24% patients showed no therapeutic effect. 22.22%, 27.27% and 26.66% disappeared clinical manifestation in ADHD-IT, ADHD-HT and ADHD-CT, respectively. 44.44%,54. 54% and 50. 0% decreased clinical manifestation in ADHD-IT, ADHD-HI, and ADHD-CT, respectively. Conclusion： Methylphenidate hydrochloride controlled-release tablets have shown significant effect on the ADHD and no adverse reaction. The adverse reaction reduces or disappears along with the time of therapy. All the patients were not found to have hypertension.