伴有淋系相关抗原表达的急性髓系白血病临床生物学特征

Clinical Features of Lymphoid Differentiation Antigens in Acute Myeloid Leukemia

目的分析淋系相关抗原在急性髓细胞白血病细胞上的表达及其临床生物学特征。方法31例患者依据骨髓细胞形态学FAB分型、细胞化学染色、流式细胞仪免疲分型确诊为伴淋系细胞标记阳性的急性髓细胞白血病（Ly＋AML），分析其临床表现和实验室指标的特征，评价疗效和预后。结果Ly＋AML的FAB分型以AML-M1／M2为主（占61％）；错译抗原以CD7最常见，其次是CD19，CD56，且均对缓解率的影响差异具有统计学意义（P〈0．05）；CD34阳性率高迭77％，以AML—M1／M2为主，是对患者预后影响力最大的因素（P=0．03）。结论Ly＋AML属特殊类型白血病，有独特的临床生物学特征。

Objective The present study was aimed to elucidate the expression features of lymphoid differentiation antigens and their clinical implications in acute myeloid leukemia （AML）. Methods 31 patients were diagnosed as Ly＋AML by morphology of bone marrow,cytochemistry and immunophenotypes of Flow cytometry. Their clinical charateristics,therapy effect and prognosis were studied. Results The results showed that Ly＋AML was more commonly in AML-M1/M2 among FAB subtypes （61%）. CD7 expression were significanty more frequent than CD19,CD56 in Ly＋AML. But they all had significantly effect on CR （P〈0. 05）. Incidence of CD34 expression was up to 77%. And it clustered in AML-M1/M2 among FAB subtypes,which the most strongest prognosis factor （P= 0. 03）. Conclusion Ly＋AML has a identical characteristics.