期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

大肠癌靶向药物治疗进展评述 被引量：2

The Advancement of Targeted Agents in the Treatment of Colorectal Cancer
下载PDF
导出
摘要 21世纪以来,靶向药物如抗VEGF的人源化单克隆抗体(Bevacizumab,贝伐单抗)和抗EGFR单克隆抗体(人鼠嵌合性单抗Cetuximab,C225,西妥昔单抗和全人源化单抗EGFR抗体,Panitumumab,帕尼单抗)的临床应用,已使复发转移性结直肠癌患者的总生存取得了长足的进步,但临床上应如何更加合理有效地使用这些药物,仍有许多亟待解决的问题。 In the 21stcentury,the integration of Oxaliplatin and Irinotecan as conventional cytotoxic agents, as well as bevacizumab and the epidermal growth factor receptor （EGFR） antibodies, cetuximab and panitumumab, as novel targeted agents into standard medical therapy have greatly improved median overall survival in metastatic CRC.However,how to use targeted drugs more reasonably and properly are still undetermined.
作者 李宇红
机构地区 中山大学肿瘤防治中心内科
出处 《医学与哲学（B）》 2010年第4期10-12,21,共4页 Medicine & Philosophy(B)
关键词 大肠癌 靶向治疗 进展 colorectal cancer,targeted therapy,progress
分类号 R735.3 [医药卫生—肿瘤]
  • 相关文献

二级参考文献7

  • 1van Cutsem E,Peeters M,Siena S,et al.Open-label,randomized,phase 3 clinical trial of Panitumumab plus best supportive care versus best supportive cave in patients with chemotherapy-refractory metastatic colorectal cancer[J].J Clin Oncol,2007,25:1658-1664.
  • 2Berlin J,Posey J,Tchekmedyian S,et al.Panitumumab with Irinotecan/Leucovorin/5-Fluorouracil for first-line treatment of metastatic colorectal cancer[J].Clin Colorectal Cancer,2007,6:427-432.
  • 3Amado RG,Wolf M,Peeters M,et al.Wildtype KRAS is required for Panitumumab efficacy in patients with metastatic colorectal cancer[J].J Clin Oncal,2008,26:1626-1634.
  • 4Hurwitz H,Fehrenbacher L,Novotny W,et al.Bevacizumab plus Irinotecan,Fluorouracil,and Leucovorin for metastatic colorectal cancer[J].N Engl J Med,2004,350:2335-2342.
  • 5Giantonio BJ,Catalano PJ,Meropol NJ,et al.Bevacizumab in combination with Oxaliplatin,Fluorouracil,and Leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer:Results from the Eastern Cooperative Oncology Group Study E3200[J].J Clin Oncol,2007,25:1539-1544.
  • 6Saltz LB,Lenz HJ,Kindler HL,et al.Randomized phase Ⅱ trial of Cetuximab,Bevacizumab,and Irinotecan compared with Cetuximab and Bevacizumab alone in Irinotecan-refractory colorectal cancer:The BOND-2 study[J].J Clin Oncol,2007,25:4557-4561.
  • 7Tol J,Koopman M,Cats A,et al.Chemotherapy,Bevacizumab,and Cetuximab in metastatic colorectal cancer[J].N Engl J Med,2009,360:563-572.

共引文献23

同被引文献22

  • 1冯波,郑民华,郑育芳,陆爱国,李健文,王明亮,马君俊,许国旺,郁宝铭.尿核苷检测在结直肠癌诊断与手术治疗监测中的应用[J].中华外科杂志,2005,43(9):564-568. 被引量：7
  • 2Zhang A H, Sun H, Wang P, et al. Modern analytical techniques in metabolomics analysis[J]. Analyst,2012,137(2) : 293-300.
  • 3He H B, Shi X Z, Chen J, et al. Metabonomics study of oral cancer u sing gas chromatography- mass spectrometry and liquid chromatogra- phy- mass spectrometry[J]. Se Pu, 2012,30(3) : 245- 251.
  • 4Rocha C M, Carrola J, Barros A S, et al. Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of blood plas- ma[J]. J ProteomeRes,2011,10(9):4314-4324.
  • 5Chen Y H, Zhang R P, Song Y M, et al. RRLC-MS/MS-based metabonomics combined with in-depth analysis of metabolic corre lation network: finding potential biomarkers for breast cancer[J]. Analyst, 2009,134 (10) : 2003 - 2011.
  • 6Chen J, Wang W Z, Lv S, et al. Metabonomics study of liver canc- er based on ultra performance liquid chromatography coupled to mass spectrometry with HILIC and RPLC separations [J]. Anal Chim Acta,2009,650(1) :3-9.
  • 7Lin L, Yu Q, Yan X M, et al. Direct infusion mass spectrometry or liquid chromatography mass spectrometry for human metabo- nomics? A serum metabonomic study of kidney cancer[J]. Ana- lyst,2010,135(11) ~2970-2978.
  • 8Garcia E, Andrews C, Hua Jia, et al. Diagnosis of early stage ovarian cancer by 1H NMR metabonomies of serum explored by use of a micro-flow NMR probe[J]. J Proteome Res,2011,10(4):1765-1771.
  • 9Jimenez B, Mirnezami R, Kinross J M, et al. 1H HR MAS NMR Spectroscopy of Tumor Induced Local Metabolic " Field- Effects" enables Colorectal Cancer Staging and Prognostication[J]. J Pro- teome Res,2012,12(2) :959-968.
  • 10Mal M, Koh P K, Cheah P Y, et al. Metabotyping of human colo- rectal cancer using two- dimensional gas chromatography mass spectrometry[J]. Anal Bioanal Chem,2012,403(2):483-493.

引证文献2

二级引证文献5

医学与哲学（B）
2010年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部