2009年贵阳市住院儿童手足口病病原学及临床特点

Clinical Feature and Pathogeny of Hand-foot-mouth Disease during 2009 Epidemic in GuiYang city

为了解贵阳地区2009年4月～9月儿童手足口病的病原学及临床特点。从住院的820例手足口病患儿中采集部分伴有重症倾向的244例患儿的肛试子和咽试子标本进行 RT-PCR技术检测，并进行临床观察。218例检测到肠道病毒，占89.34％，其中138例为EV71，占63.30％。72例为CA16，占33.02％，两者之比1.92：1。不同年龄组的病原构成差异有统计学意义（P＜0.01）。重症病例EV71感染明显高于轻症病例，两者在临床特征方面差异有统计学意义（P＜0.01）。2009年贵阳市住院儿童手足口病的主要病原是EV71和CA16；1岁-3岁的患儿EV71感染明显高于CA16， EV71比CA16更易引重症手足口病，重症病例与轻症病例在临床表现上有明显差异。

In order to find out the etiology and clinical characteristics during the epidemic of hand foot and mouth disease among the children in Guiyang between April 2009 and September 2009, 244 anal specimens and pharyngeal specimens, which have collected from 820 children who has been infected by hand foot and mouth disease.Those were tested by RT-PCR and a clinical observation has been done in the hospital. Intestinal viruses are detected in 218 cases, accounting for 89.34%, of which 138 cases of EV71, accounting for 63.30%.72 cases for CA16, accounting for33.02%, the ratio between these two viruses is 1.92：1.The pathogens of two kinds of virus infected in different age groups constitute have a statistically significant（P〈0.01）, severe cases infected by EV71 was significantly more than mild cases. The different clinical manifestations of these two virus have a statistically significant （P〈0.01）. The major pathogens of hand foot and mouth disease of children in Guiyang 2009 are EV71 and CA16.Children at the age of 1 to 3 years have a significantly higher probability to be infected by EV71 than by CA16. EV71 has a higher probability to cite more severe cases than CA16. Severe cases are significantly different at clinical appearance with mild cases.