肺炎支原体肺炎患儿血清心肌酶临床分析

Clinical analysis of activity of serological myocardial enzymes in children with mycoplasma pneumonia

目的研究血清心肌酶对肺炎支原体（MP）肺炎急性期患儿是否有心肌损害的诊断价值。方法测定48例MP肺炎患）L（MP肺炎组）血清肌酸激酶同工酶MB（CK—MB）、乳酸脱氢酶（LDH）和天冬氨酸氨基转移酶（AST）的变化。以48例健康儿童作为对照（对照组）。结果MP肺炎组急性期血清心肌酶AST（37．18±6．15）U／L、LDH（294．10±46．20）U／L、CK-MB（84．50±13．70）U几，明显高于对照组的（25．14±10．50）、（140．50±76．21）、（19．50±4．10）U／L，差异均有统计学意义（P〈0．01）。MP肺炎组恢复期血清心肌酶较急性期明显下降，但CK—MB[（27．80±8．40）U／L]、LDH[（189．50±69．73）U／L]仍高于对照组（P〈0．01或〈0．05）。结论MP肺炎急性期有不同程度的心肌损害，血清CK-MB作为MP肺炎心肌损害的生化指标特异性强，治疗MP肺炎时应注意心肌损害，及时给予保护心肌治疗。

Objective To evaluate the diagnostic value of myocardial enzymes on the cardiac muscle injury for the children with acute mycoplasma pneumonia （MP）. Method The levels of phosphocreatine kinase-MB （CK-MB）, lactate dehydrogenase （LDH）, aspartate aminotransferase （AST） in 48 children with MP （MP group）were measured, 48 normal children served as control group. Results The levels of AST, LDH, CK-MB were （ 37.18 ± 6.15 ）, （ 294.10 ± 46.20 ）, （ 84.50 ± 13.70） U/L in acute stage in MP group, they were higher than those in control group [ （25.14 ± 10.50）, （ 140.50 ± 76.21 ）, （ 19.50 ± 4.10 ） U/L] （P 〈 0.01 ）. All the values above was descended in recovery phase in MP group, but the values of CK-MB [（27.80 ±8.40） U/L] and LDH [（189.50 ± 69.73） U/L] were still higher than those in control group （P 〈 0.01 or 〈 0.05 ）. Conclusions Children with MP may combine myocardial injuries and CK-MB is a parameter to diagnose the damage. Protection therapy for cardiac muscle should be performed on the children with ME