南京社区人群甲状腺功能异常的流行病学研究

Epidemiologic study of thyroid dysfunction in community population of Nanjing

目的:研究南京社区人群甲状腺功能异常的流行病学特点。方法:采用分层整群随机抽样的方法,抽取20岁以上的常住(≥5年)居民1266人,分别进行问卷调查、体格检查和血清甲状腺功能的测定。结果:①南京地区临床甲状腺功能亢进(甲亢)、亚临床甲亢、临床甲状腺功能减退(甲减)和亚临床甲减的患病率分别为0.55%,1.74%,0.32%和4.82%;②女性人群中,临床甲亢、亚临床甲亢、临床甲减和亚临床甲减的患病率均高于男性人群,但差异未达到统计学意义;③随着年龄增长,甲状腺功能减退的患病率显著增高(ρ=0.0971,P=0.0005)。结论:甲状腺功能异常,尤其是亚临床甲状腺功能异常的患病率较高,需注意筛查、评估和干预。

Objective：To investigate the prevalence of thyroid dysfunction in Nanjing community population. Methods：The residents who had lived in Nanjing for at least five years and were more than 20 years old were selected by a stratified cluster sampling technique. 1 266 subjects were selected for questionnaire,physical examination and serum thyroid function test. Results：① Prevalences of overt hyperthyroidism,subclinical hyperthyroidism,overt hypothyroidism and subclinical hypothyroidism were 0.55%,1.74%,0.32% and 4.82% respectively in Nanjing city. ②The prevalences of overt hyperthyroidism,subclinical hyperthyroidism,overt hypothyroidism and subclinical hypothyroidism in females there all higher than those in male,however,the difference was not significant. ③ The prevalence of hypothyroidism increased significantly with age（ρ=0.0971,P=0.0005）. Conclusion：Thyroid dysfunction,especially subclinical thyroid dysfunction is common in Nanjing. Screening,evaluation and intervention for thyroid dysfunction is necessary.