注射用头孢哌酮钠与5种常用输液的配伍稳定性分析

Stability analysis of combined cefoperazone sodium for injection with five infusions

目的研究在室温20℃条件下注射用头孢哌酮钠与5种常用输液的配伍稳定性。方法将头孢哌酮钠加入5种输液中,配制成浓度为4mg.mL-1的溶液。在室温20℃下,于配伍后0、0.5、1、2、4、8h时用高效液相色谱法测定浓度,同时观察PH值及外观变化。结果配制后8h头孢哌酮钠在木糖醇注射液、0.9%氯化钠注射液中含量分别为98.96%、98.77%;在5%葡萄糖注射液、5%葡萄糖氯化钠注射液、10%葡萄糖注射液中含量有所下降,分别为96.55%、97.62%、96.43%。结论注射用头孢哌酮钠在木糖醇注射液、0.9%氯化钠注射液中稳定性最好,建议临床配伍使用。

OBJECTIVE Study the compatibility stability between Cefoperazone sodium for injection and five kinds of common used infusion.METHODS Joining the cefoperazone sodium in the five kinds of infusion,and Preparing 4mg/mL solution.At room temperature under 20℃,content determination was performed at indicated time of 0、0.5、1、2、4、8h after combination by high-performance liquid chromatography.At the same time changes in concentration,pH value and appearance were observed.RESULTS After preparation,the content of Cefoperazone sodium for injection in the xylitol,0.9% sodium chloride injection were 98.96%,98.77% along with the time within 8h;8h after the preparation of cefoperazone sodium in the xylitol injection,0.9%sodium chloride injection concentration were 98.96%,98.77%;In 5% glucose injection,5% glucose and sodium chloride injection,10% glucose injection levels was decreased to 96.55%、97.62%、96.43%.CONCLUSION Cefoperazone sodium for injection in xylitol and 0.9% sodium chloride injection in the stability of the best,it is recommended the use of compatibility in clinical.