CD44v6和E-cadherin表达与肺癌的关系

Relationship between CD44v6,E-cadherin expression and lung cancer

目的:探讨肺癌组织中CD44v6和E-钙黏附素(E-cadherin,E-CD)表达的临床意义及其相关性。方法:应用免疫组织化学方法检测65例肺癌组织中CD44v6和E-CD的表达情况,结合临床病理指标及病例随访结果进行研究分析。结果:在肺癌中CD44v6和E-CD表达阳性率分别为66.2%和53.8%。CD44v6高表达和E-CD低表达均与肺癌PTNM分期、病理分级和淋巴结转移呈正相关(均P<0.05)。肺癌CD44v6表达与E-CD表达呈负相关(r=-0.43,P<0.001)。结论:肺癌中CD44v6表达与E-CD表达密切相关,两者均可作为预测肺癌转移和评估预后的参考指标。

Objective： To study clinical significance of the expression of CD44v6 and E-cadherin（E-CD） in lung cancer and their correlation.Methods： Immunohistochemical method was used to investigate the expression of CD44v6 and E-CD protein in 65 cases of lung cancer.Results： The positive expression rate of CD44v6 and E-CD was 66.2% and 53.8% respectively in lung cancer.The overexpression of CD44v6 and the low expression of E-CD were correlated with pathological tumor node meyastasis stage,pathology grade and lymph node metastasis（all P0.05）.CD44v6 expression was negatively correlated with E-CD expression in lung cancer（r=-0.43,P0.001）.Conclusion： CD44v6 and E-CD expression have significant correlation in lung cancer.The expression of CD44v6 or E-CD is important index to evaluate the metastasis and prognosis of lung cancer.