阻塞性睡眠呼吸暂停低通气综合征患者血清脂联素水平的研究

Study of the level of adiponectin in obstructive sleep apnea-hypopnea syndrome patients

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者空腹血清脂联素水平的变化。方法:随机选择OSAHS患者组和正常对照组各40例,OSAHS患者组根据体质指数(BMI)分为肥胖组(BMI≥25,26例)和非肥胖组(BMI<25,14例)2个亚组。进行整夜睡眠呼吸监测,用酶联免疫方法测血清脂联素浓度。结果:①扣除BMI的影响后,OSAHS患者组的血清脂联素水平低于对照组(P<0.05)。②OSAHS患者组无论肥胖与否血清脂联素水平均与BMI、AHI呈负相关,与最低血氧饱和度呈正相关。结论:除外年龄、BMI因素的影响,OSAHS患者的空腹血清脂联素水平降低。OSAHS患者脂联素水平的降低独立于年龄、BMI与其AHI和最低血氧饱和度存在相关性,推测OSAHS是引起血浆脂联素水平降低的原因之一。

Objective：To investigate the change of fasting serum adiponectin in obstructive sleep apnea-hypopnea syndrome（OSAHS） patients.Method：Forty males with OSAHS and forty age-matched male normal controls were included in the study.Subjects in OSAHS group were divided into two sub-groups according to body mass index（BMI）：obese OSAHS group（BMI≥25,n=26） and non-obese group OSAHS（BMI25,n=14）.All subjects underwent an overnight sleep study.The serum adiponectin levels were measured by ELISA.Result：①Except for BMI,compared with control subjects,levels of fasting adiponectin level were significantly lower in OSAHS subjects（P0.05）.②In obese OSAHS sub-group,serum adiponectin level was negatively correlated with BMI and AHI.However,serum adiponectin level was positively correlated with the minimum oxygen saturation.There were similar correlations between serum adiponectin level and sleep parameters in non-obese OSAHS sub-group.Conclusion：Despite age and BMI,fasting adiponectin level was significantly lower in OSAHS patients than that in control subjects.And fasting adiponectin level was correlated with BMI、AHI and the minimum oxygen saturation.OSAHS is one of the main reasons of the decreased adiponectin.