脑外伤者血浆NSE含量与损伤程度的相关性

The correlation between the neuron-specific enolase quantity and brain trauma in the early stage

目的探讨血浆中神经元特异性烯醇化酶(NSE)含量与创伤性脑损伤程度的关系及法医学意义。方法选取25名健康体检者、34名颅脑损伤患者作为研究对象,根据入院时的GCS评分,将颅脑损伤患者分为轻中型组(GCS≥8分)和重型组(GCS<8分)。用酶联免疫法对上述研究对象血浆中神经元特异性烯醇化酶含量进行检测。结果在脑外伤24h内,颅脑损伤组血浆中神经元特异性烯醇化酶含量较正常对照组升高,差异有统计学意义(P<0.05),重型组与轻中型组相比,差异有统计学意义(P<0.05),血清中血浆中神经元特异性烯醇化酶含量越高,患者颅脑损伤程度越严重。结论神经元特异性烯醇化酶可作为早期检测创伤性颅脑损伤的特异性指标,其含量越高,颅脑损伤程度越重。

Objective To investigate the forensic significance of plasma neuron-specific enolase （NSE）content as an index for evaluating severity of traumatic brain injury（TBI）.Methods 25 patients with traumatic brain injury were selected and 34 volunteer were recruited as controls in the study.According to evaluation by the Glasgow Coma Scale（GCS） at admittance,TBI patients were divided into two groups,the minor or mild injury group and the severe injury group.The patients in the minor or mild injury group had GCS≥8,the patients in the severe injury group severe group had GCS8.Plasma neuron-specific enolase was determined by ELISA in the controls and patients.Results Within 24 hours after TBI,the concentration of plasma neuron-specific enolase increased in all the patients with TBI as compared with that in the control group（P0.05）.The level of plasma NSE increased higher in the severe injury group（GCS8）than in the minor or mild injury group（P0.05）.The level of plasma NSE increases with the severity of TBI.Conclusion Plasma NSE may be used as a parameter for evaluating severity of TBI,especially in the patients at earlier posttraumatic interval.