C反应蛋白与扩张型心肌病伴不同类型心房纤颤的关系研究

A Study on the Relationship between C Reactive Protein and Dilated Cardiomyopathy with Different Types of Atrial Fibrillation

目的探讨扩张型心肌病(DCM)所伴心房纤颤及心房纤颤类型是否和炎症相关。方法观察118例单纯或伴心房纤颤DCM患者左心房内径(LAD)、左心室射血分数(LVEF)、左心室舒张末内径(LVEDD)及高敏C反应蛋白(hs-CRP)水平。结果 Hs-CRP水平在DCM伴阵发性心房纤颤组及持续性心房纤颤组较单纯DCM组明显升高[(5.35±2.16)mg/Lvs(2.97±1.65)mg/L,P<0.01;(7.43±2.46)mg/Lvs(2.97±1.65)mg/L,P<0.01],伴持续性心房纤颤组hs-CRP水平高于伴阵发性心房纤颤组[(7.43±2.46)mg/Lvs(5.35±2.16)mg/L,P<0.01];初发心房纤颤和既往有心房纤颤病史患者hs-CRP水平没有明显差异(P>0.05)。结论单纯DCM、DCM伴阵发性心房纤颤、DCM伴持续性心房纤颤hs-CRP水平逐渐升高,炎症参与了DCM所伴心房纤颤的形成和维持。

ObjectiveThis study was designed to evaluate the correlation between different types of atrial fibrillation in DCM patients and inflammation.MethodsThe levels of LAD,LVEF,LVEDD and hs-CRP in 108 DCM patients with or without atrial fibrillation were observed.ResultsHs-CRP was higher in the DCM with paroxysmal or persistent atrial fibrillation group than in the DCM without atrial fibrillation group （5.35±2.16mg/L vs 2.97±1.65mg/L,P〈0.01; 7.43±2.46mg/L vs 2.97±1.65mg/L,P〈0.01）; hs-CRP was higher in the DCM with persistent atrial fibrillation group than in the DCM with paroxysmal atrial fibrillation group（7.43±246mg/L vs 5.35±216mg/L,P〈0.01）.There was no significant difference in hs-CRP level among the DCM with different history of atrial fibrillation groups （P〉0.05）.ConclusionHs-CRP level gradually elevated in DCM without atrial fibrillation,with paroxysmal and persistent atrial fibrillation patients.Inflammation was related to initiation and maintenance of atrial fibrillation in DCM patients.