鼻炎康合剂治疗变应性鼻炎的药效学研究

A pharmacodynamics study on the effects of the Biyankang Mixture on allergic rhinitis

目的观察鼻炎康合剂对变应性鼻炎的治疗作用。方法利用小鼠耳肿胀和大鼠棉球肉芽肿增生模型,观察了鼻炎康合剂的抗炎作用。应用鼻炎模型大鼠,观察了鼻炎康合剂对模型大鼠鼻黏膜病理变化、组胺的含量,鼻前庭组织中前列腺素(PGE)含量的影响。结果鼻炎康合剂对二甲苯所致小鼠耳肿胀有明显的抑制作用,能显著抑制大鼠棉球肉芽肿的增生。口服给药鼻炎康合剂,能改善鼻炎大鼠模型的炎症状态,降低鼻炎模型大鼠鼻黏膜中组胺的含量,降低鼻炎模型大鼠鼻前庭组织中前列腺素的含量影响;结论鼻炎康合剂对鼻炎模型大鼠有较好的治疗作用。

Objective To investigate the effects ofBiyankang （BYK） Mixture on allergic rhinitis. Methods Mouse auris-swell model and cotton pellet-induced granuloma model were used to be treated with BYK, and its anti-inflammatory effect was observed, and the rhino-mucosa pathological alteration, histamine and prostaglandin concentration were detected in nasal vestibule from allergic rhinitis rats. Results BYK Mixture significantly resisted the mouse auris-swel and the cotton pellet-induced granuloma, and also significantly decreased histamine and prostaglandin concentration, ameliorated the rhino- mucosa pathology. Conclusion BYK may function on allergic rhinitis through histamine and prostaglandin