人非小细胞肺癌rasP^(21)和CD_(44)的表达及意义

rasP 21 and CD 44 Expression in NSCLC and Their Significance

用免疫组化ＬＳＡＢ法检测４６例非小细胞肺癌ｒａｓＰ２１和ＣＤ４４的表达。结果：ｒａｓＰ２１的阳性率鳞癌为５９％，腺癌６３％；ＣＤ４４的阳性率鳞癌为４１％，腺癌６３％。统计学分析证明：不同临床分期的ｒａｓＰ２１表达强度有显著性差异（Ｐ＜００１）；有淋巴结转移与无淋巴结转移的ＣＤ４４表达程度有显著性差异（鳞癌Ｐ＜００１，腺癌Ｐ＜００２５）；ｒａｓＰ２１与ＣＤ４４表达强度两者无相关性（Ｐ＜００５）。结论：ｒａｓＰ２１的表达与预后不良有关，ＣＤ４４的表达与淋巴结转移有关。

The expressions of rasP 21 and CD 44 in 46 cases of non-small cell lung cancer were examined by means of immunohistochemical LSAB method.The results showed that the percentage of rasP 21 expression was 59% in squamous cell carcinoma and 63% in adenocarcinoma. The percentage of CD 44 expression was 41% in squamous cell carcinoma and 63% in adenocarcinoma. By statistical analysis,these data suggested that (1) rasP 21 expression of non-small cell lung cancer was associated with advanced tumor stage;(2) CD 44 expression of non-small cell lung cancer was associated with metastasis of lymph-node;(3) there was't any correlation between rasP 21 expression and CD 44 expression.