复方替硝唑载体栓体外抗菌活性评价

Antibiotic activity of compound tinidazole suppositor in vitro

目的研究复方替硝唑载体栓对厌氧菌、真菌及细菌体外抗菌活性。方法采用琼脂稀释法测定复方替硝载体栓对厌氧菌、真菌、细菌的最小抑菌浓度(MIC),并与妇康载体栓、甲硝唑、替硝唑、克霉唑、醋酸氯已定进行对照。结果复方替硝唑载体栓对脆弱拟杆菌、具核梭杆菌、厌氧消化链球菌、金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌、淋球菌、白色念珠菌MIC值分别为0.0 625,0.5,0.125,16,128,64,8,16μg/mL。对于标准菌株脆弱拟杆菌、具核梭杆菌、厌氧消化链球菌,复方替硝唑载体栓MIC明显低于妇康载体栓。结论复方替硝唑载体对妇科炎症具有广谱、高效杀菌特点。

Objective To study antibiotic activity of compound tinidazole carrier supositories against anaerobic bacteria,fungus and bacterium in vitro.Methods Compared with the results of the complex prescription carrier suppositeries,metronidzaole,tinidazole,coltrimaxole and chlorhexidine acetate,the minimum inhibitary concentrations（MIC） of compound tinidazle carrier suppolitories against anaerobic bacteria,fungus and bacterium were determined with agar dilution method.Results Compound tinidazole carrier suppositories showed a strong antibiotic activity against Bacteroides fragilis.Fusobacterium mucleatum,Peptostreptococcus anaerobius,Staphylococcus aureus（SA）,Escherichia coli,Pseudomonsa aeruginosa,gonococcus and Candia albicans,with MIC of 0.0625,0.5,0.125,16,128,64,8,16 μg/mL,respeetively.For Bacteroides Fragilis,Fusobacterium mucleatum,Peptostreptococus anaerobius,the MIC of compound tinidazole carrier suppositories was lower than that of the complex prescription carrier suppository.Conclusion Tinidazole carrier suppository is of broad antibiotic spectrum,high activity in vitro and low toxicity in gynecological inflamation treatment.