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胃癌组织中p8表达的初步研究 被引量：3

The Primary Research of Expression of p8 in Gastric Cancer
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摘要 目的探讨胃癌组织中p8的表达情况及意义。方法应用免疫组织化学方法检测45例胃癌组织、17例正常胃窦黏膜组织(对照组)中p8的表达情况,并分析其与胃癌患者临床特征之间的关系。结果胃癌组织中p8蛋白的表达率明显高于对照组(97.8%vs23.5%,P<0.05);且胃癌组织中p8表达强度也显著高于对照组(P<0.05)。分化低胃腺癌组织、有淋巴结转移的胃癌组织的p8表达强度分别强于高-中分化胃腺癌组织、无淋巴结转移的胃癌组织(P<0.05)。但胃癌组织中p8蛋白的表达与患者性别、年龄是否大于60岁、病变部位无明显相关(P>0.05)。结论p8可能在胃癌的发生发展中有重要作用。 Objective To explore the expression and significance of p8 in gastric cancer.Methods The expression of p8 was detected by immunohistochemistry in 45 cases of gastric cancer tissues and 17 cases of normal gastric antral mucosa.The relation between p8 expression and clinical features of patients with gastric cancer was analyzed.Results The expression rate of p8 in gastric cancer tissues was significantly higher than that in nomal antral mucosa （97.8% vs 23.5%,P0.05）,and the expression intensity of p8 in gastric cancer tissues was also higher than that in nomal antral mucosa （P0.05）.The expression intensity of p8 in poorly differentiated cancer and well-moderately differentiated cancer was higher than that in cancer tissues with lymph node metastasis and cancer tissues without lymph node metastasis,respectively （P0.05）.However,p8 protein expression had no correlation with gender,more or less 60 years old and lesion location（P0.05）.Conclusion p8 may play an important role in gastric cancinogenesis.
作者 邢军 李国华
机构地区 安徽省马鞍山市十七冶金医院内科 南昌大学第一附属医院消化内科
出处 《江西医学院学报》 CAS 2009年第12期20-22,35,F0003,共5页 Acta Academiae Medicinae Jiangxi
基金 江西省自然科学基金(0540064)
关键词 胃癌 p8 免疫组织化学 gastric cancer p8 immunohistochemistry
分类号 R735.2 [医药卫生—肿瘤]
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参考文献11

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共引文献11

同被引文献68

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引证文献3

二级引证文献7

江西医学院学报
2009年 第12期

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