期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

乳铁蛋白肽的生物学活性及应用前景

The Bio- Activities of Lactoferricin and its Application Foreground
下载PDF
导出
摘要 近年来抗菌肽已经成为研究与开发的热点，其中乳铁蛋白肽因其广泛的生物学功能而备受关注。文中阐述了乳铁蛋白肽的分子结构、生物学活性及其作用机理，讨论了乳铁蛋白肽在乳、食品和动物饲料中的应用前景，同时也提出了目前乳铁蛋白肽研究中存在的一些问题及相应对策。 Anti- microbial peptides have been the hotspots of research, and lactoferricin is the focus of them due to its broad biological function. Its molecular structure, bit - activities and acting mechanism were reviewed in this paper. The foreground of application in milk, foodstuff and animal feedstuff were also discussed. In addition, some problems and opinions during the research of lactoferricin were put forward.
作者 邢芳芳 孔祥峰 黄瑞林 张友明 印遇龙
机构地区 中国科学院亚热带农业生态研究所 中国科学院研究生院 基因桥有限股份公司
出处 《中国饲料添加剂》 2006年第10期1-5,共5页 China Feed Additive
关键词 抗菌肽 乳铁蛋白肽 生物学功能 anti - microbial peptide lactoferricin biological function
分类号 S816.7 [农业科学—饲料科学]
  • 相关文献

参考文献28

  • 1Yamauchi K, Tomlta M, Giehl TJ, EUison RT 3rd. Antibacterial activity of lactoferrin and a pepsin -derived lactofcrrin pepfide fragment [ J ]. Infect Immun, 1993, 61 (2) : 716 -728.
  • 2Bellamy W, Takase M, Yamauchi K, Wakabayashi H, Kawase K, Tomita M. Identification of the bactericidal domain of lactoferrin[J]. Biophys Acta, 1992, 1121: 130 - 136.
  • 3Strom MB, Hang B E, Rekdal Q, et al. Important structural features of 152 residue lactoferricin derivatives and methods for improvements of antimierobial activity[J]. Biochem, 2002, 80:65 -74.
  • 4Hauland H H, Vorland L H. Post 2 antibotic effect of the antimicrobial peptide lactoferrin on Eschefichia coli and Staphylococcus aureus [ J ]. J Antimicro Chemothera, 2001,48:569 -571.
  • 5Hwang, P. M. , Zhou, N. ,Shan, X. , et al. Three - dimensional solution Structure of laetoferriein B, an antimicrobial peptide derived from bovine laetoferrin[ J]. Biochemistry, 1998, 37 : 4288 - 4298.
  • 6Vogel H J, Schibli D J, Jing W, et al. Towards a structure 2 function analysis of bovine lactoferricin and related tryptophan 2 and arginine containing peptides [ J ]. Biochem, 2002, 80 : 49 - 63.
  • 7Shimazaki K, Tazume T, Uji K. Properties of heparin - binding pepfide derived from bovine laetoferrin[ J ], J Dairy Sci, 1998, 81 : 2841 -2849.
  • 8Schibili D J, Vogel P M, Hans J. The structure of: the antimierobial active center of laetoferricinB bound to sodium dodecyl sulfate micelles [ J ]. FEBS Letters, 1999, 446:213-217.
  • 9Branen J, Davidson PM. Activity of hydrolysed lactoferrin against foodborne pathogenic bacteria in growth media: the effect of EDTA [ J / OL]. Letters in Applied Microbiology, 2000, 30:233 - 237.
  • 10Wakabayashi H, Uchida K, Yamauchi K, et al. Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models[ J]. Journal of Antimicrobial Chemotherapy, 2000, 46 : 595 - 601.

二级参考文献21

  • 1Wu M,Maier E,Benz R,et al.Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli[J].Biochemistry,1999,38: 7235-7242.
  • 2Yamauchi K,Tomita M,Gichl TJ,et al.Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment[J].Infect Immun,1993,61(2):716-728.
  • 3Aguilera O,Ostolaza H,Quiros LM,et al.Permeabilizing action of an antimicrobial lactoferricin-derived peptide on bacterial and artificial membranes[J].FEBS Lett,1999,462(3): 273-277.
  • 4Wakabayashi H,Uchida K,Yamauchi K,et al.Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models[J].Joural of Antimicrobial Chemotherapy,2000,46: 595-601.
  • 5Ikeda M,Nozaki A,Sugiyama K,et al.Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells[J].Virus Research,2000,66(1): 51-63.
  • 6Zhang CH,Mann DM,Tsai CM.Neutralization of endotoxin in vitro and in vivo by a human lactoferrin-dirived peptide[J].Infect and Immun,1999,67(3) 1353-1358.
  • 7Nakamura I,Watanabe A,Tsunemitsu H,et al.Production of recombinat bovine lactoferrin N-lobe in insect cells and its anti-microbial activity[J].Protein Expression and Purification,2001,21: 424-431.
  • 8Recio I,Visser S.Two ion-exchange chromatographic methods for the isolation of antibacterial peptides from lactoferrin[J].Journal of Chromatography A,1999,831: 191-201.
  • 9Hwang PM,Zhou N,Arrowsmith CH,et al.Three-dimensional solution structure of lactoferricin B,an antimicrobial peptide derived from bovine lactoferrin[J].Biochemistry,1998,37: 4288-4298.
  • 10Jessen H,Andersen JH,Uhlin-Hansen L,et al.Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfate[J].Antiviral Research,2004,61: 101-109.

共引文献46

中国饲料添加剂
2006年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部