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内源性一氧化碳在生殖系统中作用的研究 被引量：2

The Studies on the Effect of Endogenous Carbon Monoxide in Reproductive System
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摘要 内源性一氧化碳(endogenous CO)主要由血红素加氧酶(hemeoxygenase,HO)催化分解血红素而产生,是继一氧化氮之后发现的另一种具有重要生物学效应的气体分子,广泛参与体内的各种生理和病理过程,在心血管系统、神经系统、消化系统中起非常重要的作用。近年来,其在生殖系统的研究也日益受到重视。在女性生殖系统,HO/CO不仅会影响动情周期、分娩和哺乳行为,而且会抑制受孕子宫肌层的收缩,参与保护作用。而在男性生殖系统,HO/CO能够通过抗炎、抗氧化以及抗凋亡机制保护睾丸免受应激的损伤。这种可诱导的保护性作用将成为研究的新热点。 Endogenous CO is mainly produced by enzymatic heme metabolism.This metabolism is catalyzed by heme oxygenase.It is an important gas-molecule in the body as well as NO.Endogenous carbon monoxide exerts its biological effects in many systems.Such as cardiovascular system,nervous system and digestive system.It also plays an important role in reproductive system.In female reproductive system,HO/CO can not only affect normal course of the estrous cycle,parturition and lactation,but also contribute to ueterine quiescence during pregnancy.In male reproductive system,HO/CO can protect the testicular tissue via its antioxidant,anti-inflammatory and antiapoptotic effects.In addition,these protective effects will become the new and hot spot in reproductive system research.
作者 池艳 熊承良 顾宇春
机构地区 华中科技大学同济医学院计划生育研究所 华中科技大学同济医学院生殖医学中心专科医院 英国伯明翰医学院
出处 《国际生殖健康／计划生育杂志》 CAS 2010年第2期72-74,95,共4页 Journal of International Reproductive Health/Family Planning
关键词 一氧化碳 血红素加氧酶 生殖系统 Carbon monoxide Heme oxygenase Reproductive system
分类号 R363 [医药卫生—病理学]
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参考文献20

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同被引文献24

  • 1王正朝,黄瑞华,潘玲梅,李学斌,石放雄.环核苷酸门控离子通道的结构、功能及活性调节[J].中国生物化学与分子生物学报,2006,22(4):282-288. 被引量：15
  • 2Mande JR,Kilfoy BA,Hudmon KS.Peer reviewed:tobacco control in state comprehensive cancer control plans:opportunities for decreasing tobacco-related disease.Prev Chronic Dis,2007,4(3):A61.
  • 3Munteanu I,Didilescu C.Chemistry and toxicology of cigarette smoke in the lungs.Pneumologia(Bucharest,Romania),2006,56(1):43-6.
  • 4Laubenthal J,Zlobinskaya O,Poterlowicz K,et al.Cigarette smoke-induced transgenerational alterations in genome stability in cord blood of human F1 offspring.FASEB,2012,26(10):3946-56.
  • 5Ji BT,Shu XO,Zheng W,et al.Paternal cigarette smoking and the risk of childhood cancer among offspring of nonsmoking mothers.J Natl Cancer Inst,1997,89(3):238-43.
  • 6Marinelli D,Gaspari L,Pedotti P,et al.Mini-review of studies on the effect of smoking and drinking habits on semen parameters.Int J Hyg Environ Health,2004,207(3):185-92.
  • 7Correa JR,Antypas MD,Zarmakoupis-Zavos MD,et al.Effects of seminal plasma from cigarette smokers on sperm viability and longevity.Fertil Steril,1998,69(3):425-9.
  • 8Chia SE,Tay SK,Lim ST.What constitutes a normal seminal analysis?Semen parameters of 243 fertile men.Hum Reprod,1998,13(12):3394-8.
  • 9Dunphy BC,Barratt CLR,Tongelen BP,et al.Male cigarette smoking and fecundity in couples attending an infertility clinic.Andrologia,1991,23(3):223-5.
  • 10Kapawa A,Giannakis D,Tsoukanelis K,et al.Effects of paternal cigarette smoking on testicular function,sperm fertilizing capacity,embryonic development,and blastocyst capacity for implantation in rats.Andrologia,2004,36(2):57-68.

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国际生殖健康／计划生育杂志
2010年 第2期

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