生长分化因子-9与卵泡发育和卵巢早衰

Research Progress on Growth Differentiation Factor-9,Follicular Development and Premature Ovarian Failure

生长分化因子-9是重要的卵母细胞源性生长因子。其在促进卵母细胞生长与分化以及颗粒细胞增殖、卵丘膨胀、抑制颗粒细胞和卵泡膜细胞分化的过程中起重要作用。卵巢早衰是病因不清又无有效治疗手段的复杂疾病。研究认为,卵巢内始基卵泡形成数目的减少、已形成的卵泡闭锁速度加快和对促性腺激素刺激不敏感是造成卵巢早衰的主要病因。生长分化因子-9参与了这一过程。

Growth differentiation factor-9 is an important oocyte-derived growth factor.It plays an important role in the process of promoting oocyte growth and differentiation,granulose cell proliferation,cumulus expansion and inhibitting granulose cell and follicular membrane cell differentiation.Premature ovarian failure is a complex disease that has no clear pathogenesis and effective treatment methods.Present studies show that the reduction of follicular number,the acceleration of follicular depletion and the insensitive to the follicular stimulating hormone are the primary causes of the premature ovarian failure.Growth differentiation factor-9 participates in these processes.