扬州地区脂肪肝发病率及危险因素调查

Prevalence and risk factors of fatty liver disease in Yangzhou district of China

目的探讨扬州地区健康体检人群脂肪肝的患病率及其危险因素。方法体检包括10 334例。通过超声检查肝、胆和肾脏,测量身高、体质量、血压,应用自动化分析仪检测空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血尿酸(BUA)。结果总人群、男性、女性脂肪肝患病率分别为20.4%、26.2%、8.0%,60岁以下各年龄段脂肪肝患病率男性高于女性(P<0.01)。脂肪肝组肥胖、高血压、高血糖、高TC、高TG、低HDL-C、高LDL-C、高BUA、胆结石、肾结石的患病率高于对照组(P<0.01)。多因素logistic回归分析表明脂肪肝的危险因素包括高TG、高血糖、高BUA、高血压、男性、低HDL-C、高BMI。结论扬州地区脂肪肝的患病率较高,其危险因素包括高TG、高血糖、高BUA、高血压、男性、低HDL-C、肥胖。

Objective To explore the prevalence of fatty liver disease（FLD） and its risk factors in Yangzhou district,China. Methods In total, 10 334 subjects were investigated for FLD. FLD was determined by ultrasonography. Body height, body mass, blood pressure（ BP）, fasting plasma glucose （ FPG）, serum triglyceride （ TG）, total cholesterol （TC） ,low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDI.-C） and blood uric acid （BUA） were determined by routine laboratory methods. Results The incidence of FLD in total people,male and female in the study were 20.4%,26.2% and 8.0%. The rate was higher of FLD in male than in female in 〈60 years old groups （ P 〈0. 01 ）. The prevalenees of obesity, hypertension, high FPG, high TC, high TG, low HDL-C, high LDL-C, high BUA,gallstone and kidney stone were higher in FLD than in the controls（ P 〈0.01）. Multiple logistic regression analysis revealed that risk factors of FLD included high TG, high FPG, high BUA, hypertension,male, low HDL-C and obesity. Conclusion A high prevalence of FLD was found in Yangzhou area, the risk factors for FLD were associated with high TG,high FPG,high BUA,hypertension,male,low HDL-C and high BMI.