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成纤维细胞生长因子-23对牙发育的影响和作用

The roles of fibroblast growth factor-23 in the development of teeth
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摘要 成纤维细胞生长因子(FGF)-23是X连锁显性低磷血症、常染色体显性遗传性低磷血症以及肿瘤诱发性骨软化症等低磷血症的共同致病因子,不仅产生于骨组织,也产生于牙等矿化组织,即FGF-23可能参与了牙胚发育的调节。下面就FGF-23的结构和生化特性、血磷调节机制和在牙胚发育中的表达以及X染色体同源内肽酶磷酸盐调节基因突变对牙胚中FGF-23表达的影响、FGF-23过表达对牙胚发育的影响等研究作一综述。 Fibroblast growth factor（FGF）-23 was identified in recent years as a new phosphaturic factor that is associated with the pathogenesis of hypophosphatemic rickets and osteomalacia,such as X-linked hypophosphatemia,autosomai dominant hypophosphatemic rickets and tumbur-induced osteomalacia.Recently,it is found that FGF-23 is not only expressed in osteoblast,but also in odontoblast,which suggests that FGF-23 may regulate the development of teeth germ.Here,we will summarize the expression and effects of FGF-23 in teeth development.
作者 郭可武 郭丛丛 汪华
机构地区 中山大学光华口腔医学院口腔医学研究所 中山大学光华口腔医学院.附属口腔医院口腔病理科
出处 《国际口腔医学杂志》 CAS 2010年第2期186-188,共3页 International Journal of Stomatology
基金 中山大学二期985工程基金资助项目(985-2008-70)
关键词 成纤维细胞生长因子-23 牙 矿化不全 X染色体同源内肽酶磷酸盐调节基因 fibroblast growth factor-23 teeth mineralization imperfect phosphate regulating gene with homologies to endopeptidase on the X chromosome
分类号 R78 [医药卫生—口腔医学]
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参考文献13

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二级参考文献23

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  • 9The ADHR Consortium. Autosomal dominant hypophosphatemic rickets is associated with mutations in FGF-23. Nat Genet, 2000,26: 345-348.
  • 10Jonnson KB, Zahraadnik R, Larsson T, et al. Fibroblast growth factor 23in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med,2003,348:1656-1663.

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国际口腔医学杂志
2010年 第2期

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