双氯芬酸钠乳剂预防PICC致机械性静脉炎的效果观察

Efficacy of diclofenac diethylamine emulgel on the prevention of PICC-induced mechanic phlebitis

目的观察双氯芬酸钠乳剂对预防PICC置管后机械性静脉炎的效果。方法将100例行PICC穿刺术的肿瘤患者按单双日分组,单日为观察组50例,PICC置管后即给予双氯芬酸钠乳剂外涂,3次/d,0.95g/次,连续7d;双日为对照组50例,对照组置管后即给予多磺酸黏多糖乳膏,方法同双氯芬酸钠乳剂。结果双氯芬酸钠乳剂观察组机械性静脉炎的发生率为4%,多磺酸黏多糖乳膏对照组机械性静脉炎的发生率为8%,差异无统计学意义(P>0.05)。结论双氯芬酸钠乳剂预防PICC致机械性静脉炎的疗效同多磺酸黏多糖乳膏,两者同样具备操作简单、方便、等优点,但双氯芬酸钠乳剂的价格优于多磺酸黏多糖乳膏,值得推广应用。

Objective To investigate the efficacy of externally applied diclofenac diethylamine emulgel on the prevention of PICC-induced mechanic phlebitis.Methods One hundred cancer patients with PICC were divided into two groups.diclofenac diethylamine emulgel and mucopolysaccharide polysulfate cream were applied three times a day for 7 days after catheterization in the two groups,respectively.Results There was no significant difference on the incidence of mechanic phlebitis between the two groups（4% vs.8%,P〉0.05）.Conclusion The efficacy of externally applied diclofenac diethylamine emulgel on the prevention of PICC-induced mechanic phlebitis is the same as mucopolysaccharide polysulfate cream.Except their common virtue of convenient and simple operation,the price of diclofenac diethylamine emulgel is lower than mucopolysaccharide polysulfate cream and worthy to be spread in clinical practice.