蜂胶软胶囊调节血脂作用研究

Blood Lipid Regulating Function of Propolis Soft Capsules

研究蜂胶软胶囊对高血脂大鼠血脂代谢的影响。本实验采用60只雄性SD大鼠为实验动物,随机分为6组:低(83.3mg/(kgbw·d))、中(250mg/(kgbw·d))、高(500mg/(kgbw·d))的3个蜂胶剂量组,阴性(普通饲料组)、阳性(高脂饲料组)、溶剂(植物油)对照组。分别连续灌胃30d,同时设采尾血进行血脂水平的测定。结果表明:中、高两剂量组大鼠血清甘油三酯(TG)、血清总胆固醇(TC)水平显著低于溶剂及阳性对照组,血清HDL-C水平各组间无明显差异。结论:蜂胶软胶囊有极好的辅助调节高脂血症大鼠血脂的功能。

To evaluate the effect of propolis soft capsules on blood lipid metabolism in rats with high fat diet-induced hyperlipidemia,60 SD male rats were used as experimental animals and randomly divided into 6 groups designated as propolis groups fed high fat diet and orally administered low,middle and high doses（83.3,250 mg/（kg bw·d）） and 500 mg/（kg bw·d）） of propolis,negative control group fed normal diet group and orally administered distilled water,positive control group fed high fat diet and orally administered distilled water,and solvent control group fed high fat diet and orally administered vegetable oil.All the animals were conducted corresponding administrations for 30 consecutive days.Tail vein blood was harvested for blood lipid analysis.Results indicated that TC and TG levels in the low-and high-dose propolis groups were significantly lower than those in the solvent control group.The 6 groups did not significantly differ in serum HDL-C level.Therefore,propolis soft capsules have excellent function in regulating blood lipid level in rats with hyperlipidemia.