苦瓜皂甙预防去卵巢大鼠骨质疏松的实验研究

Preventive Effect of Momordica charantia L.Saponins on Osteoporosis in Ovariectomized Rats

以去卵巢骨质疏松症模型大鼠为研究对象,以血清参数、骨密度(BMD)、股骨和子宫组织形态为指标,研究连续给与苦瓜皂甙65、130、260mg/(kgbw·d)12周后对去卵巢大鼠骨质疏松的预防作用。结果表明:苦瓜皂甙用药组大鼠与模型组相比较血清雌二醇、Ca2+水平提高,股骨骨密度提高,股骨近端干骺端骨组织形态得到改善,而体质量、子宫质量以及子宫组织形态与模型组大鼠无显著差异。因此,苦瓜皂甙可预防去卵巢大鼠骨质疏松的形成。

To consider the potential of Momordica charantia L.saponins in preventing osteoporosis,female SD ovariectomized rats with osteoporosis were used as experimental animals.The rats were divided into 4 groups designated as one model and 3 experimental groups administered Momordica charantia L.saponins at the doses of 65,130 mg/（kg bw·d） and 260 mg/（kg bw·d） for 12 consecutive weeks.After the administration,blood parameters and bone mineral density（BMD） of rats were measured and pathomorphism of femur and uterus were observed as well.Compared with the osteoporosis model group,serum E2 and Ca2＋ levels and bone mineral density（BMD） of the experimental groups exhibited an obvious increase.Wider trabecular bone and smaller medullary cavity were also observed in the experimental groups.However,no difference in body weight,uterus weight and uterus pathomorphism was observed between rats with and without Momordica charantia L.saponins treatments.The above findings demonstrate a preventive effect of Momordica charantia L.saponins on osteoporosis in ovariectomized rats.