摘要
研究西青果提取物对小肠α-葡萄糖苷酶的抑制作用。西青果提取物在体外和小肠模型人类结肠Caco-2细胞中,显示很强的麦芽糖酶抑制活性,而对蔗糖酶的抑制作用不显著。在体内实验中,西青果提取物能降低SD雄性大鼠进食麦芽糖30min后的血糖,而对进食蔗糖后的血糖浓度没有影响。实验结果表明西青果提取物可以预防Ⅱ型糖尿病。
In order to evaluate the inhibitory effect of Terminalia chebula Retz fruit extract(TCFE) on α-glucosidase,Caco2 cells were used to assay the inhibitory activity of TCFE in vitro and in small intestinal model.Results indicated that TCFE exhibited a strong inhibitory effect on maltase,while no obvious inhibitory activity on sucrase in vitro was observed.In addition,TCFE also obviously reduced 30 min postadministration blood glucose level of SD maltose-loaded male rats.On the other hand,this extract had no effect on the postprandial blood glucose level in normal SD rats administrated sucrose.These results suggest that TCFE has a preventive effect against Type Ⅱ diabetes.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2010年第7期284-287,共4页
Food Science
基金
四川大学人才引进科研启动项目(0082204127126)
关键词
西青果
Α-葡萄糖苷酶抑制剂
血糖
糖尿病
Terminalia chebula Retz.
α-glucosidase inhibitor
blood glucose level
diabetes