妊娠奶牛奶对雌性SD幼鼠生长发育和血脂的影响

Effect of Pregnant Cow's Milk on Growth and Development and Blood Lipid of Juvenile Female SD Rats

目的:观察妊娠奶牛奶对雌性SD幼鼠生长发育和血脂的影响。方法:64只21日龄雌性SD幼鼠,随机等分为4组,分别定量喂食妊娠奶牛奶、产后奶牛奶、市售纯牛奶和实验配方奶。于29日龄和54日龄时观察生长发育指标并检测血脂等。结果:上述4组54日龄时血清高密度脂蛋白胆固醇(HDL-C)浓度分别为(0.66±0.07)、(0.60±0.04)、(0.69±0.07)mmol/L和(0.56±0.12)mmol/L,其中妊娠奶牛奶组高于实验配方奶组(P<0.05),市售纯牛奶组高于产后奶牛奶和实验配方奶组(P<0.05),其余各组间差异均无统计学意义;29日龄时其各组间差异也无统计学意义。29日龄及54日龄时血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇组间差异均无统计学意义。结论:妊娠奶牛奶或以妊娠奶牛奶为主的市售纯牛奶可能升高雌性SD幼鼠血清HDL-C水平。

Objective：To investigate the effect of pregnant cow＇s milk on growth and development and blood lipid of juvenile female SD（Sprague-Dawley） rats.Methods：Sixty-four female SD rats aged 21 days old were randomly divided into 4 groups,which were fed pregnant cow＇s milk,postpartum cow＇s milk,commercial whole milk（mainly from pregnant cows） and artificial milk.The growth and development index of rats were observed and their blood lipid level was determined at 29 and 54 days old.Results：There was no statistically significant difference in serum high-density lipoprotein cholesterol（HDL-C） among 4 groups at 29 days old.Serum HDL-C levels in rats fed pregnant cow＇s milk,postpartum cow＇s milk,commercial whole milk and artificial milk were（0.66 ± 0.07）,（0.60 ± 0.04）,（0.69 ± 0.07） mmol/L and（0.56 ± 0.12） mmol/L at 54 days old,respectively.In addition,serum HDL-C level in rats fed pregnant cow＇s milk was higher than that in rats fed artificial milk（P〈0.05）,and serum HDL-C level in rats fed commercial whole milk was higher than that in rats fed postpartum cow＇s milk or artificial milk（P〈0.05）.No statistically significant difference in serum total cholesterol,triglyeride and low-density lipoprotein cholesterol among 4 groups at 29 or 54 days old was observed.Conclusion：The use of pregnant cow＇s milk or commercial whole milk can increase serum HDL-C in juvenile female SD rats.