超临界二氧化碳萃取橘核中诺米林的工艺研究

Response Surface Optimization of Supercritical Carbon Dioxide Extraction of Nomilin from Citrus Seeds

采用响应曲面法优化超临界CO2萃取橘核中诺米林的工艺条件,考察萃取压力、萃取温度、夹带剂用量对诺米林萃取量的影响。结果表明诺米林的优化萃取条件为萃取压力25MPa、萃取温度51℃、夹带剂用量1.5mL/g,在此条件下诺米林萃取量为(6.27±0.06)mg/g。

Response surface methodology based on a central composite design involving 15 experiments of 3 variables at 3 levels was used to optimize nomilin yield at different levels of key supercritical carbon dioxide extraction parameters such as extraction pressure and temperature and entrainer（95% ethanol） dosage.Results showed that the optimal levels of these parameters for achieving a maximum nomilin yield of（6.27±0.06） mg/g were as follows：extraction pressure 25 MPa,51 ℃ and entainer dosage 1.5 mL/g.