摘要
目的:观察阿维A联合白芍总苷治疗寻常型银屑病的临床疗效。方法:81例符合条件的患者随机分为2组,对照组40例口服阿维A0.5mg·kg-1·d-1,症状好转后改为0.1~0.2mg·kg-1·d-1;治疗组41例在对照组的基础上加服白芍总苷0.6mg,tid。2组均外用冰黄肤乐霜。疗程均为8周。治疗前、后检查2组患者的血尿常规、肝肾功能及血脂含量,并观察患者的不良反应。结果:治疗组有效率为90.2%,对照组为62.5%,2组有效率差异有显著性(P<0.05);治疗组患者的不良反应显著低于对照组(P<0.05)。结论:阿维A联合白芍总苷治疗寻常型银屑病近期疗效明显,且不良反应少,安全性高。
OBJECTIVE:To observe clinical efficacy of acitretin combined with TGP in the treatment of psoriasis vulgaris. METHODS:81 patients were randomized into control group(n=40)and treatment group(n=41). Control group were treated with 0.5 mg·kg-1·d-1acitretin then the dose of acitretin was adjusted to 0.1~0.2 mg·kg-1·d-1after clinical symptom improved.Treat-treatment course. Blood and urine routine,liver and kidney function and the level of blood lipid of 2 groups were detected before and after 8 weeks treatment as well as ADR. RESULTS:The total response rate was 90.2% for treatment group and 62.5% for control group,there were significant difference(P0.05). Adverse reaction of patients in treatment group was strikingly lower than in control group. CONCLUSION:Acitretin combined with TCP have significant effect on psoriasis vulgaris with less ADR and good safety.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第16期1492-1493,共2页
China Pharmacy