阿维A联合白芍总苷治疗寻常型银屑病的疗效观察

Efficacy Observation of Acitretin Combined with TGP in the Treatment of Psoriasis Vulgaris

目的:观察阿维A联合白芍总苷治疗寻常型银屑病的临床疗效。方法:81例符合条件的患者随机分为2组,对照组40例口服阿维A0.5mg·kg-1·d-1,症状好转后改为0.1～0.2mg·kg-1·d-1;治疗组41例在对照组的基础上加服白芍总苷0.6mg,tid。2组均外用冰黄肤乐霜。疗程均为8周。治疗前、后检查2组患者的血尿常规、肝肾功能及血脂含量,并观察患者的不良反应。结果:治疗组有效率为90.2%,对照组为62.5%,2组有效率差异有显著性(P<0.05);治疗组患者的不良反应显著低于对照组(P<0.05)。结论:阿维A联合白芍总苷治疗寻常型银屑病近期疗效明显,且不良反应少,安全性高。

OBJECTIVE：To observe clinical efficacy of acitretin combined with TGP in the treatment of psoriasis vulgaris. METHODS：81 patients were randomized into control group（n=40）and treatment group（n=41）. Control group were treated with 0.5 mg·kg-1·d-1acitretin then the dose of acitretin was adjusted to 0.1～0.2 mg·kg-1·d-1after clinical symptom improved.Treat-treatment course. Blood and urine routine,liver and kidney function and the level of blood lipid of 2 groups were detected before and after 8 weeks treatment as well as ADR. RESULTS：The total response rate was 90.2% for treatment group and 62.5% for control group,there were significant difference（P0.05）. Adverse reaction of patients in treatment group was strikingly lower than in control group. CONCLUSION：Acitretin combined with TCP have significant effect on psoriasis vulgaris with less ADR and good safety.