头孢唑啉与头孢呋辛预防剖宫产术切口感染的疗效比较

Efficacy of Cefazolin vs. Cefuroxime in Preventioning Cesarean Section Wound Infection

目的:比较头孢唑啉与头孢呋辛预防剖宫产围手术期切口感染的疗效。方法:291例择期行剖宫产手术患者,根据用药情况随机分为A组(n=140)、B组(n=151),进行回顾性分析。A组术前30min静脉滴注头孢唑啉2.0g;术后2～5d,每12h静脉滴注头孢唑啉2.0g。B组术前30min静脉滴注头孢呋辛2.0g;术后2～5d,每12h静脉滴注头孢呋辛2.0g。比较2组患者的临床疗效。结果:2组患者术后白细胞计数、中性粒细胞百分比、血红蛋白、并发症、体温、伤口愈合情况均无统计学差异(P>0.05),均未见药品不良反应。结论:头孢唑啉与头孢呋辛预防剖宫产切口感染的疗效相当。

OBJECTIVE：To compare the efficacy of cefazolin and cefuroxime prevention of perioperative cesarean section wound infection. METHODS：291 cases of elective cesarean section surgery,according to the use of medicines are divided into group A（n=140）and group B（n=151）,were retrospectively analyzed. Patients in group A,preoperative 30 min intravenous infusion of cefazolin 2.0 g;after surgery,2.0 g ivgtt,q12 h,continue to use 2～5 days. Patients in group B,preoperative 30 min intravenous infusion of cefuroxime 2.0 g;after surgery,2.0 g ivgtt,q12 h,continue to use 2～5 days. Comparison of the clinical effect of 2 groups patients. RESULTS：WBC,N%,Hb,complications,body temperature,wound healing had no statistical difference in postoperative between 2 groups. All patients were not the emergence of drug adverse reactions. CONCLUSION：cefazolin and cefuroxime has the same efficacy of prevention of cesarean section wound infection.