期刊文献+

盐酸罗哌卡因注射液的含量测定 被引量:2

下载PDF
导出
摘要 目的:建立盐酸罗哌卡因注射液含量测定的高效液相色谱测定法。方法:色谱柱:Agilent C_(18)(150 mm×4.6 mm,5μm),流动相:乙腈-磷酸缓冲液(取1 mol·L^(-1)磷酸二氢钠液1.3 ml;0.5 mol·L^(-1)磷酸氢二钠32.5ml,加水至1000ml,用10%的磷酸调节pH为8.0)(60:40),检测波长:262nm,流速:1.0 ml·min^(-1)。结果:盐酸罗哌卡因在0.061 4~1.228 mg·ml^(-1)浓度范围内,与峰面积呈良好的线性关系(r=0.999 7),平均回收率为99.85%,RSD=0.64%(n=9)。结论:该方法简便,结果准确,专属性强,灵敏度高,能够有效控制产品的质量。
作者 张浩 江莹
出处 《中国药师》 CAS 2010年第5期738-740,共3页 China Pharmacist
  • 相关文献

参考文献4

二级参考文献31

  • 1吴新民.罗哌卡因临床验证总结.1999年4月
  • 2Wildsmith JAW,Brown DT,Paul D,et al. Structure-activity relationship in differential nerve black at high and low frequency stimulation. Br J Anesth, 1989,63: 52
  • 3Lee A,Fagan D,Lamont M,et al. Disposition Kinetic of ropivacaine in humans. Anesth Analg, 1989,67: 736
  • 4Emanuelsson BM,Magnusson A,Alm C,et al. Pharmacokinetics of ropivacaine after Three i. v. doses. Clin Pharmacol Ther, 1994,55:123
  • 5Halldin MM, Elofsson S. Metabolism and Excretion of ropivacaine in animals. Abstract. 11th European Workshop on Drug Metabolism, 1998,12:11
  • 6Bader AM,Datta S,Flanagan H,et al. Comparison of bupivacaine and ropivacaine induced conduction in blockade in the isolated rabbit vagus nerve. Anesth Analg, 1989,68: 724
  • 7Zaric D,Nydahl PA,Philipson L,et al. The effect of continuous lumbar epidural infusion of ropivacaine (0. 1%, 0. 2 % and 0. 3 % )and 0. 25% bupivacaine on sensory and motor block in volunteers. Reg Anesth, 1996,21:14
  • 8Scott DB,LeeA,Fagan D,et al. Acute toxicity of ropivacaine compared with that of bupivacaine. Anesth Analg, 1989,69: 563
  • 9Arlock P. Action of three local anaesthetics-lidocaine, bupivacaine and ropivacaine on guinea-pig papillary muscle sodium channels (Vmax). Pharmacol Toxicol, 1998,63: 96
  • 10Feldman H,Pitkanen M,Arthur Gr,et al. Effects of ropivacaine,bupivacaine and lidocaine on the spontaneously beation rabbit heart. Anesthesiology, 1990,73: A844

共引文献109

同被引文献13

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部