头孢他啶治疗儿童细菌性下呼吸道感染的疗效观察

Clinical Efficacy of Ceftazidime for Bacterial Lower Respiratory Infection in Children

目的:探讨头孢他啶治疗儿童细菌性下呼吸道感染的临床疗效和安全性。方法:将80例细菌性下呼吸道感染的儿童随机分为观察组40例和对照组40例,观察组采用头孢他啶60mg·kg-1·d-1,分2次静脉滴注;对照组采用氨苄西林钠100～200mg·kg-1·d-1,分2次静脉滴注;两组疗程均为5d,然后比较两组患儿的治疗效果。结果:观察组和对照的有效率分别为95.00%、72.50%;观察组和对照的不良反应率分别10.00%和25.00%;两组间差异存在显著性(P<0.05)。结论:头孢他啶治疗儿童细菌性下呼吸道感染安全有效,值得临床推广应用。

OBJECTIVE：To explore the clinical efficacy and safety of ceftazidime for bacterial lower respiratory infection in children.METHODS：80 children with bacterial lower respiratory infection were randomly assigned to either intervention group（n = 40 cases） treated with ceftazidime 60 mg·kg-1 ·d-1 i.v in two divided doses or the control group（n = 40 cases） treated with ampicillin sodium 100 ～ 200 mg·kg-1·d-1 i.v in two divided doses for 5 days followed by comparison of the clinical efficacy between the two groups.RESULTS：The clinical efficacy of the intervention group vs.the control group was 95.00% vs.72.50% and the incidence of the adverse effect was 10.00% and 25.00%,and the differences were all significant（P 0.05）.CONCLUSION：Ceftazidime is safe and effective for bacterial lower respiratory infection in children,and hence is worthy of being recommended in clinical practice.