益气养阴活血方对糖尿病肾病大鼠的影响

Effect of supplementing qi and nourishing yin and promoting blood flow formula on diabetic nephropathy rats

目的:观察益气养阴活血方对糖尿病肾病大鼠的治疗作用。方法:用链脲佐菌素腹腔注射制备糖尿病肾病大鼠模型,模型大鼠随机分为空白对照组(正常组)、模型组、贝那普利治疗组(贝那普利组)和益气养阴活血方治疗组(中药组),并用相应的药物干预,给药8w后检测各组大鼠血糖、血清果糖胺、血脂、血肌酐和24h尿蛋白定量、尿β2微球蛋白水平等指标。结果:益气养阴活血方和贝那普利对糖尿病肾病大鼠肾组织、24h尿蛋白定量、血脂、血清果糖胺、血肌酐、尿β2微球蛋白水平等均有改善作用,中药组大鼠尿蛋白由(11.21±2.66)mg/24h降为(9.37±0.73)mg/24h(P<0.01)。结论:益气养阴活血方对糖尿病肾病大鼠具有治疗作用。

Objective：To observe the therapeutic effect of supplementing qi and nourishing yin and promoting blood flow formula on diabetic nephropathy rats.Methods：SD rats were randomly divided into four groups：control group,model group,Benazepril-treatment group and Chinese medicine treatment group.The latter three groups were induced to be diabetic nephropathy by intraperitoneal injection with strepotozocin and then were treated respectively.After eight weeks,blood glucose,serum fructosamine,blood fat,serum creatinine,urinary protein,urinary β2-M were determined.Results：Compared with model group,histology of kidney,urinary protein,blood fat,serum fructosamine,Scr,urinary β2-M were improved in Benazepril-treatment group and Chinese medicine treatment group.The 24-hour urine protein were reduced from（11.21±2.66）mg/24h to（9.37±0.73）mg/24h in Chinese medicine treatment group（P〈0.01）.Conclusion：Supplementing qi and nourishing yin and promoting blood flow formula had the therapeutic effects on diabetic nephropathy rats.