维生素D、维生素D受体与支气管哮喘

Vitamin D, vitamin D receptor, and bronchial asthma

越来越多证据表明，维生素D与支气管哮喘（简称哮喘）发病有关，主要机制包括维生素D和环境危险因素等共同作用导致免疫系统的失衡，以及维生素D影响胚胎肺发育等。本文主要综述维生素D、维生素D受体和免疫系统之间的关系，以及维生素D如何通过免疫学机制影响哮喘发病方面的研究进展。深入研究维生素D、维生素D受体在哮喘发病中所起的作用及作用机制．有助于进一步阐明哮喘的发病机制，从而为哮喘的预防和治疗提供新的途径。

Accumulating evidence suggests that vitamin D is associated with asthma etiology, including interactions of vitamin D and enviornmental risk factors on immune imbalance,and influence of vitamin D on lung maturation. This review will mainly involve the relationships among vitamin D and the immune system, and how vitamin D influences the onset of asthma through the regulation of immune reaction. Better understanding the roles of vitamin D and vitamin D receptor in asthma pathogenesis in which they mediate may be helpful in reversing the recently rising prevalence of asthma, and provides a potential way to asthma prevention and treatment.