期刊文献+

支气管哮喘气道平滑肌生长的生化机制

Biomechanism of airway smooth muscle growth in bronchial asthma
原文传递
导出
摘要 支气管哮喘都有气道平滑肌的生长,并引起气道的狭窄和气流阻塞,其分子机制和气道重塑而发生的功能改变仍然不清楚。这篇综述将讨论气道平滑肌增生、肥大以及功能的改变和发生的生化机制。 Airway smooth muscle growth lies in bronchial asthma and leads to narrowing and airflow obstruction of the airway, whose molecular mechanism and functional effect of remodeling of airway remains unclear. This review will discuss airway smooth muscle hyperplasia, hypertrophy and biomechanism of them.
出处 《国际呼吸杂志》 2010年第3期162-165,共4页 International Journal of Respiration
关键词 支气管哮喘 气道平滑肌 增生 肥大 Bronchial asthma Airway smooth muscle Hyperplasia Hypertrophy
  • 相关文献

参考文献28

  • 1Huber HL,Koessler KK.The pathology of bronchial asthma.Arch Intern Med,1922,30:689-760.
  • 2Ebina M,Takahashi T,Chiba T,et al.Cellular hypertrophy and hyperplasia of airway smooth muscles underlying bronchial asthma.A 3-D morphometric study.Am Rev Respir Dis,1993,148:720-726.
  • 3Ma X,Cheng Z,Kong H,et al.Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects.Am J Physiol Lung Cell Mol Physiol,2002,283:L1181-L1189.
  • 4Leguillette R,Lauzon AM.Molecular mechanics of smooth muscle contractile proteins in airway hyperresponsiveness and asthma.Proc Am Thorac Soc,2008,5,40-46.
  • 5Gil FR,Zitouni NB,Azoulay E,et al.Smooth muscle myosin isoform expression and LC20 phosphorylation in innate rat airway hyperresponsiveness.Am J Physiol Lung Cell Mol Physiol,2006,291:L932-L940.
  • 6Salmon M,Liu YC,Mak JC,et al.Contribution of upregulated airway endothelin-1 expression to airway smooth muscle and epithelial cell DNA synthesis after repeated allergen exposure of sensitized Brown-Norway rats.Am J Respir Cell Mol Biol,2000,23:618-625.
  • 7Zheng X,Zhou D,Seow CY,et al.Cardiotrophin-1 alters airway smooth muscle structure and mechanical properties in airway explants.Am J Physiol Lung Cell Mol Physiol,2004.287:L1165-L1171.
  • 8Zhou D,Zheng X,Wang L,et al.Expression and effects of cardiotrophin-1(CT-1)in human airway smooth muscle cells.Br J Pharmacol,2003,140:1237-1244.
  • 9Woodruff PG.Gene expression in asthmatic airway smooth muscle.Proc Am Thorac Soc,2008,5:113-118.
  • 10Goldsmith AM,Bentley JK,Zhou L,et al.Transforming growth factor-beta induces airway smooth muscle hypertrophy.Am J Respir Cell Mol Biol,2006,34,247-254.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部