粒细胞-巨噬细胞集落刺激因子与支气管哮喘的研究进展

Research advances on relationgship between Granulocyte-macrophage colony stimulating factor and bronchial asthma

粒细胞-巨噬细胞集落刺激因子（GM—CSF）可以由支气管哮喘（简称哮喘）炎症部位的巨噬细胞、嗜酸粒细胞和上皮细胞产生。反之，GM-CSF也同样作用于巨噬细胞、嗜酸粒细胞、免疫细胞、中性粒细胞等。GM—CSF的高表达增强了机体对抗原的敏感性，导致气道炎症反应增加，在哮喘发病机制中起着重要作用。

Granuloeyte macrophage colony stimulating factor （GM-CSF） is produced by macrophages, eosinophils and epithelial cells under the airway inflammation of bronchial asthma （asthma）. However,GM-CSF also effects macrophages, eosinophils, immunocytes, neutrophils, et al. It has been shown that hyperexpression of GM-CSF promotes sensitization to allergens, resulting in augmentation of airway inflammation. So GM-CSF may play an important role in the pathogenesis of asthma.