磁共振弥散加权成像在兔良恶性淋巴结鉴别中的价值

Value of MR diffusion weighted imaging in discrimination between benign and malignant lymph nodes in rabbit model

目的:采用动物模型研究MR弥散加权成像评价转移性淋巴结与反应增生性淋巴结的价值。方法:24只新西兰兔随机分成两组,分别制作转移性淋巴结与反应增生性淋巴结模型,比较两组淋巴结的表观弥散系数(ADC),同时在DWI图上测量并比较两组淋巴结与肌肉的相对信号强度,并进行病理结果分析。结果:两组淋巴结的DWI相对信号强度无显著性差异(P>0.05)。转移性淋巴结组ADC值大于反应性增生组ADC值,分别为0.82±0.10×10-3mm2/s和1.17±0.14×10-3mm2/s,差异有统计学意义(P<0.05)。

Objective： To investigate the value of MR diffusion weighted imaging in evaluation of metastatic and reactive proliferative lymph nodes. Methods： 24 New Zealand rabbit were randomly divided into two groups, metastatic and reactive proliferative lymph nodes models were made respectively. ADC values of lymph nodes in the two groups were compared. Meanwhile, the relative signal intensity to muscle on the DWI images of the lymph nodes in the two groups were measured and compared. Pathologic analysis were performed afterward. Results： There was no significant difference between relative signal intensity of lymph nodes in the two groups（P〉0. 05）.ADC value of metastatic lymph node group was less than that of reactive proliferative lymph nodes group. The ADC value was 0.82±0.10×10^-3mm^3/s and 1.17± 0.14×10^-3mm^3/s respectively, and the difference was significant（P〈0.05）. Conclusion： MR diffusion weighted imaging （DWI） is helpful in differentiation of metastatic and reactive proliferative lymph nodes.