放射性核素碘治疗对甲亢性心脏病患者血浆ET、TNF-α及IL-1水平的影响

Effect of radionuclide iodine therapy on ET and TNF-α and IL-1 levels of hyperthyroid heart patients

目的:观察放射性核素碘(131I)治疗对甲亢性心脏病(甲亢心)患者治疗前后血内皮素(ET)、肿瘤坏死因子-α(TNF-α)及白细胞介素-1(IL-1)水平的影响,探讨ET、TNF-α及IL-1与甲亢心的关系。方法:采用酶联免疫吸附法(ELISA)测定测定63例单纯甲状腺功能亢进症(单纯甲亢组)患者以及86例甲亢心患者(甲亢心组)131I治疗前后血ET、TNF-α及IL-1的含量,并观察甲状腺激素水平的变化。结果:131I治疗甲亢心组患者前后血ET、TNF-α及IL-1均显著高于单纯甲亢组;甲亢心组患者131I治疗后血ET、TNF-α、IL-1、FT3及FT4显著下降,而TSH水平增高(P<0.05)。结论:131I可调节甲亢心患者血ET、TNF-α、IL-1的分泌,上述因子水平变化与甲亢心患者的甲状腺功能和心功能的改善密切相关。

Objective： To observe the effect of the radionuclides iodine （131I） treatment on endothelin （ET） and tumor necrosis factor-α （TNF-α） and interleukin-1 （IL-1） levels in the plasma of the thyrotoxic heart disease, and to explore the relationship between the ET, TNF-α and IL-I and thyrotoxic heart disease. Methods： Enzyme-linked immunosorbent assay （ELISA） was used to measure the ET and TNF-α and IL-1 content in blood of 63 cases of simple hyperthyroidism patients （alone hyperthyroidism group） and 86 cases of thyrotoxic heart disease patients （hyperthyroid heart group） betbre and after with 131I treatment, and to observe the changes in thyroid hormone levels. Results： The ET and TNF-α and IL-I content in the blood of thyrotoxic heart disease group before and aider with 131I treatment were significantly higher than that of alone hyperthyroidism group, the ET and TNF-α and IL-I FT3 and FT4 level in the blood of thyrotoxic heart disease group after 131I treatment decreased significantly, while the TSH level increased （ P〈0.05 ）. Conclusion：131I can regulate the ET, TNF-α , IL-I secretion in the blood of hyperthyroid heart patients, these factor levels in patients is closely related to the improvement of thyroid function and cardiac function of thyrotoxic heart disease.