p53、survivin在食管癌中的作用

Effect of survivin and C-myc protein expression in esophageal carcinoma

目的:检测p53和survivin蛋白在食管癌组织中的表达,探讨其意义。方法:应用免疫组织化学法检测食管癌及正常食管粘膜组织中p53、survivin蛋白的表达情况。结果:p53、survivin在食管癌组织中的表达量均高于正常食管粘膜组织(P<0.05),p53、survivin高表达与食管癌淋巴结转移状况差异有关(P<0.05),与性别、年龄、肿瘤长度、浸润深度、分化程度无关(P>0.05)。p53和survivin蛋白在食管癌中表达呈明显正相关性(R=0.218,P<0.05)。结论:p53、survivin在食管癌中高表达(82.1%&71.9%),二者在食管癌的淋巴结转移中发挥重要作用,并具有协同作用。

Objective： To detect the expression ofsurvivin ,p53 protein in esophageal carcinoma, and to elucidate the relationship of their protein expression and their clinicalsignificance. Methods： We detected survivin, p53 protein expression in esophageal carcinoma and normal mucous membrane of esophagus by immunohistochemistry method. Results： The expression rates of survivin, p53 protein were significant different in esophageal carcinoma, and normal mucous membrane of esophagus. In addition, the expression rate of survivin and p53 protein were correlated with lymph node metastasis. Conclusions： The dys-regulation of survivin and p53 expression may correlate the occurrence and development of esophageal carcinoma.