胃癌组织中15-PGDH的表达特征及其临床意义

Expression and clinical significance of 15-hydroxyprostaglandin dehydrogenase in gastric cancer

目的:探讨15-羟基前列腺素脱氢酶(15-PGDH)在胃癌组织和癌旁正常组织中的表达及其与临床病理特征的关系,初步评价15-PGDH在胃癌发生、发展中的作用及其意义。方法:随机收集60例胃癌手术病人的癌组织及相应癌旁正常组织,应用免疫组织化学检测15-PGDH表达特征并进行评分,进一步分析15-PGDH的表达与胃癌临床病理参数的关系。结果:胃癌组织中15-PGDH的表达水平显著降低甚至缺失(p<0.01)。结合胃癌的临床病理学特征统计分析表明,15-PGDH在低分化胃癌中明显低于高分化胃癌中的表达(p<0.05);15-PGDH在TNMⅢ期和Ⅳ期患者的胃癌组织中的染色明显低于在Ⅰ期和Ⅱ期组织中的表达(p<0.05);存在淋巴结转移的胃癌组织中15-PGDH表达显著低于无淋巴结转移胃癌组织中的表达(p<0.01)。结论:胃癌中15-PGDH的表达减少或缺失可能是胃癌发生、发展及浸润转移的重要机制之一,15-PGDH在胃癌中可能扮演着抑癌基因的角色。

Objective：To investigate the expression and clinical significance of 15-hydroxyprostaglandin dehydrogenase （15-PGDH） protein in gastric cancer. Methods：Immunohistochemistry was used to detect the expression of 15-PGDH protein in 60 gastric cancer tissues and adjacent non-tumor tissues. Statistic analyses were explored to value its relation with the clinicopathological parameters. Results： 15-PGDH expression was found decreased or even absent in gastric cancer tissues compared with the corresponding non-tumor tissues. Further analysis about its relationship with clinicopathological parameters revealed that the level of 15-PGDH was significantly lower in patients of Ⅲ-Ⅳ stage than in Ⅰ-Ⅱ stage （p〈0.05）. Its expression had significant difference among differentiation grade （p〈0.05） and was related with lymph node metastasis （p〈0.01）. Conclusions：The expression of 15-PGDH is decreased or even absent in gastric cancer tissues. The results suggest that 15-PGDH may play its role in gastric carcinogenesis and progression as a tumor suppressor.