雾化吸入治疗婴幼儿重度哮喘的研究

Inhalation Therapy for Infants and Children with Severe Asthma

目的：比较婴幼儿哮喘重度发作时，采用布地奈德混悬液吸入治疗和全身用甲基强的松龙的效果。方法：将78例哮喘重度发作婴幼儿按就诊顺序分为2组，分别采用布地奈德混悬液＋万托林雾化（布地奈德纽，35例）、万托林雾化＋静脉用甲泼尼龙（甲泼尼龙组，43例）治疗，对其临床症状进行比较。结果：组内不同治疗时间患儿呼吸频率、心率、哮鸣音及自我感觉评分均随时间延长而逐渐降低，与治疗前比较差异有统计学意义（q=2．89-143．87，P〈0．05或0．01）；组间比较，各组指标无显著性差异。结论：提示婴幼儿哮喘重度发作时，采用布地奈德混悬液吸入治疗可达到与静脉用甲泼尼龙基本相同的效果；联合吸入治疗在一定程度上可代替全身用激素。

Objective：To compare the effects ofbudesonide inhalation suspension and body treatment with methylprednisolone in Infants Asthma at severe attack.Methods：The 78 cases of infants and young children with severe asthma attacks were divided into two groups according to treatment sequence, one group was given budesonide suspension ＋ Ventolin inhalation Coudesonide group, 35 cases）, the other group was given Ventolin inhalation ＋ intravenous methylprednisolone （methylprednisolone group,43 cases）, Compared with their clinical symptoms. Results：It is indicated that compared with those before treatment in different treatment time, respiratory rate, heart rate, wheeze score and self-feeling score were gradually decreased with time, difference was significantly （q= 2.89-143.87, P〈0.05 or 0.01）, but no significant difference can be seen between the two groups. Conclusions：It is suggested that infants and young children with severe asthma attack, budesonide suspension can achieve the same effect as intravenous methylprednisolone; in a certain extent, combined inhalation therapy can replace the systemic use of glucocorticoid.