晚期炎症介质-高迁移率族蛋白B-1

Late inflammatory mediator as high mobility group albumen-1

高迁移率族蛋白-1(HMGB-1)是一类广泛存在于真核细胞内的非组核蛋白,是由肿瘤坏死因子(TNF-a)刺激巨噬细胞分泌。HMGB-1全身性炎症反应失控性发展是致使组织损伤和器官衰竭的根本原因,在脓毒症HMGB-1升高程度与感染严重性呈正相关。HMGB-1是炎症晚期重要介质,抑制HMGB-1能够预防内毒素和细菌攻击所致MODS,改善严重脓毒症的预后。尽管对HMGB-1防治作用的确切机制与应用效果尚待深入探讨,但HMGB-1为临床干预脓毒症提供了较宽的时间窗。

high mobility group albumen-1 （HMGB-1）was macrophage secrete excited by tumor necrosis factor （TNF-a）,a group of negative rib nucleoprotein widespread indwell eukaryon intracellular. HMGB-1 all over the body inflammation reaction out of control development is result in the tissues have been injury and organ prostration of fundamental cause. HMGB-1 heightens degree and was infected with severity to offer positive correlation in premie. HMGB-1 is important of the late of inflammatory mediator, restrain HMGB-1 can be prevented end toxin and bacterium an attack of incur MODS, to improve graveness pyemia after recover. The articles sum up HMGB-1 research and action mechanism.