早期生长反应基因-1与肿瘤的关系

Relations of early growth response gene-1 and tumor

早期生长反应基因-1属即刻早期基因家族，是一种重要的转录因子，至少调控着30种基因的转录，直接或间接地参与细胞的生长、分化、凋亡、免疫应答、损伤和修复。大量研究表明，早期生长反应基因-1在肿瘤细胞中表达消失，外源性早期生长反应基因-1的导入有抑制肿瘤细胞生长的作用。另有研究表明早期生长反应基因-1具有辐射诱导性，其在肿瘤放射治疗中具有潜在的临床应用前景。

Early growth response gene-1 （Egr-1） ,one of the immediate early genes,is an important transcription factor, which regulates at least thirty kinds of genes＇ transcription. It can be directly or indirectly involved in cell growth, differentiation, apoptosis, immune response, injury and repair. A large number of studies have shown that Egr-1 expression disappears in tumor cells,exogenous Egr-1 can inhibit the growth of tumor cells. Other studies have shown that Egr-1 has radiation inducibility,and has potential clinical application in radiotherapy of tumor.