生存素与肿瘤信号转导通路之间的关系

Relationship between survivin and signal transduction pathway in tumor

生存素是凋亡抑制蛋白家族新成员，是细胞增殖和凋亡调控界面间的“结点”分子。生存素基因表达的肿瘤特异性使其成为目前恶性肿瘤诊断和治疗的新靶点。肿瘤细胞发生与正常细胞的信号通路异常有关，信号转导通路的活化参与细胞癌变、增殖、凋亡等多种生物学效应。本文就肿瘤中信号转导对生存素基因的表达调控机制的研究进展作一综述。

Survivin belongs to the member of inhibitor of apoptosis protein family, which is the ＂node＂ molecule between cell proliferation and apoptosis regulation. The expression of survivin gene possesses tumor specificity,which makes survivin as a new target for diagnosis and therapy of malignant tumor. Tumor cytogenesis is related to abnormal signal pathway of normal cells. The activation of signal transduction pathway is involved in carcinogenesis, proliferation, apoptosis and other biological effects. This article reviews the research progress of the signal transduction in the survivin gene expression and regulation mechanism of tumor.