阿托伐他汀对脑梗塞患者血脂及高敏C反应蛋白影响的临床研究

Study of atorvastatin in patients with cerebral infarction lipids and high-sensitivity C-reactive protein

目的:探讨阿托伐他汀对脑梗塞患者血脂及高敏C反应蛋白(hs-CRP)值的影响。方法:选取48例脑梗塞合并高脂血症的患者,随机分为2个组,即阿托伐他汀组(24例)和辛伐他汀组(24例),观察患者用药前后血脂及hs-CRP值的变化。结果:患者在用药4 w后,阿托伐他汀组和辛伐他汀组血清中甘油三酯、总胆固醇、低密度脂蛋白均显著降低(P<0.05),差异具有显著性;阿托伐他汀组和辛伐他汀组hs-CRP值均显著降低(P<0.05),但阿托伐他汀组降低更为明显(P<0.05)。结论:阿托伐他汀可在短时间内降低脑梗塞患者的血脂及hs-CRP值,从而降低脑血管疾病的发生。

Objective：To investigate the effect of atorvastatin on serum lipids in patients with cerebral infarction and high-sensitivity C-reactive protein（hs-CRP） value of impact.Methods：48 cases of cerebral infarction in patients with combined hyperlipidemia were randomly divided into two groups.Atorvastatin group（24 cases） and simvastatin（24 cases） group were observed before and after treatment in patients with blood lipid and hs-CRP changes.Results：4 weeks after the atorvastatin group and the simvastatin group serum triglyceride,total cholesterol,low-density lipoprotein were significantly lower（P0.05）,and difference was significant;atorvastatin group and simvastatin group hs-CRP were significantly lower（P0.05）,Atorvastatin group,but more significantly reduced（P0.05）.Conclusion：Atorvastatin reduces cerebral infarction in a short time in patients with blood lipid and hs-CRP value,thereby reducing the incidence of cerebrovascular diseases.