芦荟多糖对高原重度创伤失血性休克大鼠的治疗效果

Effects of Aloe polysaccharide on severe traumatic-hemorrhagic shock at high altitude in rats

目的:探讨芦荟多糖(AP)对高原重度创伤失血性休克大鼠的治疗效果。方法:初进高原30只雄性SD大鼠随机分为3组:乳酸林格氏液组(LR,10只);芦荟多糖组(AP50,AP100各10只)。实验中持续监测平均动脉血压(MAP),并在放血前(T0)、休克1 h(T3)、复苏1 h末(T5)、2 h末(T7)测动脉血气,记录大鼠生存时间和4 h生存率。结果:AP可显著提升重度创伤失血性休克大鼠MAP,改善动脉血气指标,明显延长动物存活时间。结论:AP有较好的治疗高原重度创伤失血性休克的作用,且AP 100μg/ml是相对较好的剂量。

Objective： To explore the effects of Aloe polysaccharide（AP） on severe traumatic-hemorrhagic shock in rats at high altitude.Methods： Thirty male rats,first transported to the place of 3 780 meters above the sea level,were randomly divided into 3 groups.The rats of Lactated Ringer＇s solution group（LR） were resuscitated with 1.5 times of LR.In AP group,the rats were resuscitated with 50 μg/ml or 100 μg/ml AP which was added to the 1.5 times of LR.Mean arterial pressure（MAP） was monitored continuously,arterial blood gas was measured before blood withdrawal（T0）,1 h after shock（T3）,at the end of 1 h（T5）,2 h（T7） of resuscitation.The survival time and survival rate of 4 h were recorded.Results： AP significantly increased MAP,improved the variables of blood gases,and prolonged the survival time.Conclusion： AP at a concentration of 100 μg/ml has a beneficial effect in the treatment of severe traumatic-hemorrhagic shock at high altitude.