围生期脑静脉血栓形成与FV Leiden突变的关系

The Relationship between Peripartum Intracranial Venous Thrombosis and Factor V Leiden Mutation

目的探讨围生期脑静脉血栓形成与凝血因子V Leiden突变的关系。方法应用聚合酶链反应-限制性片段长度多态性PCR技术(PCR-RFLP)对广州地区汉族8例围生期脑静脉血栓形成及50例正常妊娠妇女进行凝血因子V Leiden突变研究分析。结果58例研究对象中未发现凝血因子V Leiden突变。结论FVL突变作为广州地区汉族妇女围生期脑静脉血栓形成的主要危险因素的可能性较小,广州地区汉族妇女FVL突变率较低。

Objective To explore the relationship between peripartum intracranial venous thrombosis and factor V Leiden mutation.Methods Polymerase Chain Reaction-Restriction Fragment Length Polymorphism was employed to study factor V Leiden mutation in 8 cases of peripartum intracranial venous thrombosis and 50 normal pregnant women.Results Factor V Leiden mutation was not found in all 58 study subjects.Conclusion There is a slim possibility that factor V Leiden mutation is the major risk factor for peripartum intracranial venous thrombosis in Han women in Guangzhou area.The mutation rate in factor V Leiden in Han women in Guangzhou area is low.