藏药中金属铜对继发性棘球蚴病小鼠体内细胞因子影响

Treatment of Murine Secondary Cysts of Echinococcus granulosus with Tibetan Drugs

目的应用藏药二十五味铜灰散的成分之一—自然铜和天竺黄治疗小鼠继发性棘球蚴病,探讨——药物治疗感染棘球蚴的小鼠后其体内细胞因子的变化趋势。方法感染棘球蚴小鼠给予藏药、自然铜及其它药物治疗90d后,剖杀小鼠眼球获取小鼠血清。检测小鼠血清中的细胞因子IL-2、IL-6、IL-10和IgE的含量。结果治疗90d后,小鼠血清IL-2、IL-6和IgE的含量与对照组比较差异有统计学意义(P<0.05),IL-10的含量与对照组比较差异无统计学意义。结论小鼠血清中的细胞因子IL-2、IL-6、IL-10和IgE的含量可作为判断治疗棘球蚴病的疗效指标。

Objective To study the effect of Tibetan drugs,the copper,on the levels of cytokines in mice with experimental secondary cysts of Echinococcus granulosus.Methods After ninety days of treatment,blood samples were taken from eyeball after the mice were dissected,and the serum levels of IL-2,IL-6,IL-10 and IgE were measured.Results The results showed that a significant differences of the serum levels of IL-2,IL-6 and IgE between treated and control groups（P〈0.05）,but not that of IL-10（P〉0.05）.Conclusion IL-2,IL-6,IL-10 and IgE can de used as indicators of the treatment of secondary cycsts of Echinococcus granulosus.