血清胱抑素C对糖尿病肾病诊断价值的Meta分析

Meta-Analysis of Diagnostic Values of Serum Cystatin C in Diabetic Nephropathy Patients

目的评价血清胱抑素C在诊断糖尿病肾病中的价值。方法检索多个数据库,对相关文献进行系统评价,用随机效应模型计算纳入研究的总灵敏度、特异度及其它指标,绘制受试者工作特征曲线以探讨本试验的总体诊断特性。结果按照选择标准最终有9项独立研究纳入本次meta分析,合并灵敏度与特异度分别为85%和86%,合并阳性拟然比与阴性拟然比分别为6.23和0.17,合并诊断优势比为54.59,SROC曲线下面积0.9435,SE为0.0273。结论血清胱抑素C水平的检测有助于评估肾小球滤过功能,对糖尿病肾病患者早期肾损害有一定的诊断价值。

Objective To evaluate the value of serum Cystatin C in the diagnosis of diabetic nephropathy.Methods Systematic review of various data bases was performed in this study.Data on the sensitivity,specificity and other measures of value of pleural concentrations of Cystatin C in the diagnosis of diabetic nephropathy were pooled and analyzed using random effects models.Summary receiver operating characteristic（SROC） curves were used to summarize the overall test performance.Results Data from nine independent studies were analyzed.Meta-analyses showed that the pooled sensitivity was 0.85 and the pooled specificity was 0.86.The pooled positive likelihood ratio,pooled negative likelihood ratio and the pooled diagnostic odds ratio was 6.23,0.17 and 54.59,respectively.Area under the SROC curve was 0.9435 and the SE was 0.0273.Conclusion Cys C is useful in the valuation of glomerular filtration function and it also has a diagnostic value in the diagnosis of early diabetic nephropathy.