PPARγ和MMP-9在妊娠期高血压疾病患者胎盘组织的表达及其临床意义

Expressions and clinical significance of PPARγ and MMP-9 in placental tissues of patients with hypertensive disorder-complicating pregnancy

目的探讨PPARγ和MMP-9在妊娠期高血压疾病(HDCP)发生发展中的表达及其临床意义。方法利用免疫组化SP法检测正常妊娠者31例(对照组)和HDCP患者36例(实验组)胎盘组织中PPARγ、MMP-9表达,探讨其与HDCP的关系。结果①PPARγ在实验组胎盘组织中明显高表达,与对照组比较有显著差异(P<0.05),PPARγ阳性表达率随病情加重而显著增高。②MMP-9在实验组胎盘组织中呈低表达,与对照组比较有显著差异(P<0.05),MMP-9阳性表达率随病情加重而显著降低。③PPARγ与MMP-9的Pearman相关分析显示二者表达水平呈负相关(r=-0.529,P<0.01)。结论PPARγ在HDCP患者胎盘中呈高表达,MMP-9在HDCP患者胎盘中呈低表达,提示其可能通过抑制滋养细胞的浸润能力而参与HDCP的发病。

Objective To investigate the expressions and clinical significance of PPARγ and MMP-9 in the genesis and development of hypertensive disorder-complicating pregnancy（HDCP）.Methods The expressions of PPARγ and MMP-9 in placenta of 31 normal pregnant women（control group） and 36 pregnant women with hypertensive disorder-complicating pregnancy（experimental group） were detected by using SP method of immunohistochemistry,and the relationship between PPARγ and MMP-9 expressions and hypertensive disorder-complicating pregnancy was explored.Results ① PPARγ expression in placental tissues was significantly higher in the experimental group than in the control group（P〈0.05）;PPARγ with positive expression rate of exacerbations was significantly increased.② MMP-9 expression in placental tissues showed low expression in the experimental group,which was significantly different from that in the control group（P〈0.05）;MMP-9 with positive expression rate of exacerbations was significantly decreased.③ The Pearman correlation analysis of PPARγ and MMP-9 showed that the expression level of the two had a negative correlation（r=-0.529,P〈0.01）.Conclusion PPARγ has a high expression in the placenta of patients with HDCP while MMP-9 has a low expression,suggesting that they may be involved in the pathogenesis of HDCP by inhibiting the infiltration capacity of nourishing cells.