存活素在尖锐湿疣皮损中的表达

Expression Level of Survivin in Condyloma Acuminatum

目的:探讨凋亡抑制基因存活素在男性包皮尖锐湿疣组织中的表达。方法:采用免疫组化染色法检测30例男性包皮尖锐湿疣皮损组织及30例正常男性包皮组织中存活素表达水平。结果:尖锐湿疣组中存活素蛋白表达水平显著高于对照组(P<0.01),两组表达阳性率差异有统计学意义。结论:存活素在尖锐湿疣组织中呈高表达状态,可能在尖锐湿疣的发病中起重要作用。

Objective：To investigate the expression of Survivin in the skin lesion of male condyloma acuminatum patients. Methods： The expression levels of Survivin were measured by immunohistochemistry in 30 cases of condyloma acuminatum and 30 cases of normal foreskin lesions. Results：Higher expression level of Survivin was detected in condyloma acuminatum lesions, com- pared to that in normal lesions by immunohistochemical study（P 〈0.01 ）. There was a statistical significance in the expression level of Survivin between the two groups. Conelusion：Survivin was strongly expressed in condyloma acuminatum lesions. It may play an important role in the pathogenesis of condyloma acuminatum.