茄尼醇的纯化工艺研究

Study on Purification of Solanesol

以茄尼醇粗品为原料,利用皂化柱层析法进行纯化。对皂化工艺参数进行了正交试验优化,得到皂化最佳工艺参数为:茄尼醇粗品50 g,乙醇用量250 mL,20%氢氧化钠溶液20 mL,在80℃下反应3 h。柱层析以6#溶剂油-乙酸乙酯(体积比10∶1)洗脱,得到的产品收率达到14%,纯度达95.8%。

Crude solanesol was purified using saponification followed by column chromatography. The saponification conditions were optimized based on the orthogonal test. Results showed that the optimal conditions were as follows： crude solanesol 50 g, ethanol 250 mL, 20 % NaOH solution 20 mL, temperature 80 ℃ and reaction time 3 h. Using 6# solvent oil-acetic ether （ 10： 1, volumn ratio） as eluant for column separation, the yield and purity of the product were 14 % and 95.8 %, respectively.